Research points to the ECG as a broad biomarker

Conditions linked to signatures in the ECG

Identified by unsupervised AI models in a study published last year.

A single, low-cost test that is already part of routine care carries far more information than it has traditionally been used for. That finding is the foundation our work is built on.

Friedman et al., npj Digital Medicine, 2025

Read the study

Why we started with aortic stenosis and hyperkalemia

Of the hundreds of conditions the ECG may reveal, we chose our first two deliberately. Each one meets four criteria.

Aortic stenosis

Left untreated, mortality can be as high as 50% two years after onset of severe symptomatic aortic stenosis.

Up to half of cases are missed until after death.

Valve replacement is an established, effective treatment.

Reviews ECGs already stored in health records to flag who needs an echocardiogram.

Hyperkalemia

Hyperkalemia is a leading cause of discontinuation of GDMT for CKD and HF patients, which significantly increases mortality.

Often has no symptoms, and today can only be diagnosed with a blood draw.

Medication changes and potassium-lowering therapies can bring levels back under control.

Uses single-lead ECG from wearables, such as smartwatches, to monitor outside the clinic.

Aortic stenosis screening from stored ECGs

Earlier detection can open access to effective treatment, improving outcomes and lowering costs.

Aortic stenosis is a narrowing of the heart's aortic valve that makes the heart work harder with every beat.

It progresses slowly, often without clear symptoms, and severe cases left untreated carry high mortality.

The definitive test, an echocardiogram, is ordered only when a clinician already suspects the disease.

The ECG is one of the most common tests in medicine, and it can capture electrical remodeling associated with aortic stenosis.

AK-AVS is AI software designed to review ECGs already stored in health system records, identify potential cases of moderate to severe aortic stenosis, and help clinicians prioritize who should receive an echocardiogram.

AK-AVS: early results

In a published validation study, AK-AVS identified aortic stenosis in routine ECGs years before patients needed valve replacement.

Read the study

earlier identification, before transcatheter valve replacement (TAVR)

European Heart Journal – Digital Health, 2026

higher risk of aortic stenosis hospitalization in patients flagged before echocardiography showed disease

European Heart Journal – Digital Health, 2026

Sensitivity vs auscultation

Source: [publication, year]

The film's title card: AK+ Guard, AI hyperkalemia monitoring via Lead I ECG0:50

AI hyperkalemia monitoring via Lead I ECG

Earlier warning of rising potassium can give clinicians time to act before it becomes an emergency.

Hyperkalemia is a buildup of potassium in the blood. It is often silent, yet at moderate to severe levels it can disrupt the heart's rhythm and lead to sudden cardiac arrest.

People with chronic kidney disease and end-stage renal disease are at highest risk.

Patients with chronic kidney disease and heart failure are at risk for hyperkalemia and the very medications they take to protect their heart and kidneys exacerbate the risk of hyperkalemia.

Managing physicians often stop or reduce therapy to prevent hyperkalemia if they see an elevated potassium lab. Shifting from guideline directed medical therapy significantly higher mortality.

ECGs can be captured by commonly used wearables, to enable remote monitoring outside of a clinical environment.

AK+ Guard is AI software designed to use Lead I ECG data from wearables, including smartwatches, to alert patients and clinicians to potential moderate to severe hyperkalemia between clinic visits.

AK+ Guard: early results

AK+ Guard was validated retrospectively across three large health systems, with results measured against serum potassium from a standard blood test.

in retrospective clinical validation on late stage CKD patients

Source: [study registry or publication]

Published research and recognition

A figure seen through reeded glass in warm amber light

The ECG as a broad biomarker

Our approach, methods and early results in one document.

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  • Aortic stenosis[Title of AK-AVS validation study][Journal] · [Year]
  • Hyperkalemia[Title of AK+ Guard study][Journal] · [Year]
  • Platform[Title of AccurECG performance study][Journal] · [Year]
  • HyperkalemiaBest New ECG Technology Solution, AK+ GuardMedTech Breakthrough Awards · 2026

Our beachheads are just the beginning

  1. Now

    • Aortic stenosis
    • Hyperkalemia
  2. Next

    • Other structural heart disease
    • Other electrolyte disorders
    • Heart failure
    • Cardiomyopathies
  3. Beyond the heart

    • Liver dysfunction
    • Other areas where the ECG carries a signal